SS-31 Peptide:
SS-31 peptide (Szeto-Schiller-31), also known as MTP-131, is a tetrapeptide that has garnered interest for its potential properties related to mitochondrial dysfunction. (1)
With a unique characteristic of holding a cationic 3+ charge at physiological pH. This molecule appears to permeate cell membranes with ease and potentially traverses the blood-brain barrier. It has been suggested to rapidly exit cells, despite not being a substrate for P-glycoprotein.
One of the most researched attributes of SS-31 is its potential to accumulate in the inner mitochondrial membrane at concentrations that appear to be over 1000 times greater than in plasma. In this environment, SS-31 50mg may interact with cardiolipin, an anionic phospholipid unique to the inner mitochondrial membrane.
Researchers suggest that this binding disrupts the interactions between cardiolipin and cytochrome C.This leads to a reduction in the oxidative inactivation of cardiolipin by cytochrome C. The mechanism of SS-31 peptide may involve inhibiting the peroxidase activity of cytochrome c. While preserving Met80-heme ligation and favoring its electron carrier activity. Given that researchers suggest cardiolipin plays a pivotal role in optimizing mitochondrial electron transport and ATP production. This disruption has significant potential.
It may help in the formation of mitochondrial cristae, guaranteeing efficient oxidative phosphorylation and minimizing the leakage of reactive oxygen species.
At Pepsynth Labs, our SS-31 (50mg) attracts attention in mitochondrial studies that explore cellular energy potential.



